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Nauseavomitingloss of appetitemouth soresdiarrheaor constipation may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

As hydroxyurea is mainly eliminated from the body via the kidneysdose reductions may be necessary in patients with reduced kidney function.

Hydroxyurea causes severe myelosuppressionTreatment with hydroxyurea should not be initiated if bone marrow function is markedly depressedBone marrow suppression may occurand leukopenia is generally its first and most common manifestationThrombocytopenia and anemia occur less often and are seldom seen without a preceding leukopeniaBone marrow depression is more likely in patients who have previously received radiotherapy or cytotoxic cancer chemotherapeutic agentsuse hydroxyurea cautiously in such patients.

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